Effects of dietary lead and/or dimercaptosuccinic acid exposure on regional serotonin and serotonin metabolite content in rainbow trout (Oncorhynchus mykiss)
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Acknowledgements
This research was supported by a National Institute of Environmental Health Sciences grant ES04184 awarded to David H. Petering and a National Institutes of Health grant DA95-015 awarded to R.E.S.
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Cross-species coherence in effects and modes of action in support of causality determinations in the U.S. Environmental Protection Agency's Integrated Science Assessment for Lead
2015, ToxicologyCitation Excerpt :Thus, the lines of evidence demonstrating the effects of Pb on disruption of calcium homeostasis as well as alterations in neurotransmitter regulation and release describe a plausible sequence of key events in the MOA for the nervous system effects of Pb. Pb exposure has been shown to affect gamma-aminobutyric acid (GABA), serotonin, and dopamine, with effects on GABA found in nematodes and experimental rodents (Du and Wang, 2009; Lasley and Gilbert, 2002) and effects on serotonin found in experimental rats and also in fathead minnow and rainbow trout (Virgolini et al., 2008; Sloman et al., 2005; Rademacher et al., 2003; Weber et al., 1991). These effects were demonstrated by several different investigators and often with blood Pb levels (means 10–27 μg/dL, see Table 5) considered relevant to U.S. air-related exposures.
Comparative study of 17 β-estradiol on endocrine disruption and biotransformation in fingerlings and juveniles of Japanese sea bass Lateolabrax japonicus
2014, Marine Pollution BulletinCitation Excerpt :It has been reported that serotonin modulates cell renewal, proliferation and migration of numerous cell types (Azmitia, 2001). Furthermore it has been documented that contaminants can modulate the presence of 5-HT in different tissues of invertebrates and vertebrates (Almeida et al., 2003; Antonio et al., 2002; Rademacher et al., 2003). Brain serotogenic system plays a pivotal role in neuroendocrine function to defend the homeostasis during physiological or environmental change.
A small heat shock protein (sHSP) from Sinonovacula constricta against heavy metals stresses
2013, Fish and Shellfish ImmunologyCitation Excerpt :It has been well documented that Pb2+ interacts with a variety of molecules involved in signal transduction, such as Ca2+ channels, Ca2+ binding proteins, and Ca2+-dependent protein kinases [20]. Pb2+ could also disrupt metabolic pathways [21], and change neurotransmitter balance [22] in higher animals. The linkage of Pb2+ and small sHSPs was detected by Leal et al. [23] who reported that Pb2+ can modulate the phosphorylation state of Hsp27 via activation of the p38MAPK pathway.
Effects of acute and chronic waterborne lead exposure on the swimming performance and aerobic scope of fathead minnows (Pimephales promelas)
2011, Comparative Biochemistry and Physiology - C Toxicology and PharmacologyCitation Excerpt :Furthermore, a follow-up study revealed behavioral impairment in larval offspring exposed to Pb as assessed by a prey capture assay (Mager et al., 2010). Aside from lordoscoliosis (Davies et al., 1976; Holcombe et al., 1976), other effects of Pb to the nervous system of fish have been reported including the disruption of various neurotransmitter systems (Rademacher et al., 2003; Sloman et al., 2005; Spieler et al., 1995), increased brain endocannabinoid levels (Rademacher et al., 2005) and injury to the hippocampus and optic tetum, regions of the brain controlling memory and visuomotor function (Giusi et al., 2008). Although the Pb concentration was higher than used in the present study (1450 nmol L− 1; 300 μg L− 1), Weber and Dingel (1997) found a 38% decrease in Ucrit of rainbow trout (Oncorhynchus mykiss) following 1 week of Pb exposure that was attributed to neurobehavioral dysfunction as assessed by separate analyses of neurotransmitter levels and the startle response of fathead minnows.
Lead
2011, Fish PhysiologyCitation Excerpt :However, from the limited number of studies available it would seem that the effects are consistent with those observed in mammals. Lead has been found to affect various neurotransmitter systems in fish, including serotonergic (Spieler et al., 1995; Rademacher et al., 2003; Sloman et al., 2005) dopaminergic (Spieler et al., 1995; Rademacher et al., 2001), and noradrenergic (Spieler et al., 1995) pathways. In addition, Pb increased brain endocannabinoid levels in male fathead minnows, likely accentuating Pb-induced effects on neurotransmitter release (Rademacher et al., 2005).
Specific cerebral heat shock proteins and histamine receptor cross-talking mechanisms promote distinct lead-dependent neurotoxic responses in teleosts
2008, Toxicology and Applied Pharmacology