Elsevier

Neuroscience Letters

Volume 347, Issue 3, 28 August 2003, Pages 179-182
Neuroscience Letters

Spinal nerve ligation induces transient upregulation of tumor necrosis factor receptors 1 and 2 in injured and adjacent uninjured dorsal root ganglia in the rat

https://doi.org/10.1016/S0304-3940(03)00695-5Get rights and content

Abstract

Evidence indicates a role for tumor necrosis factor-alpha (TNF) in neuropathic pain. We correlated pain behavior in response to mechanical stimulation with immunoreactivity for TNF receptor (TNFR) 1 and 2 at 6, 24, 76 and 120 h following L5 and L6 spinal nerve ligation (SNL). Allodynia began in both L4 and L5 dermatomes within 6 h following SNL, peaking by 24 h. In L5 (injured) dorsal root ganglia (DRG), TNFR1 and TNFR2 levels displayed a bimodal increase, peaking at 6 and 120 h after SNL. In L4 (uninjured) DRG, TNFR1 and TNFR2 immunoreactivity peaked at 24 h returning to basal levels by 120 h. TNFR upregulation in injured and adjacent uninjured DRG neurons may be essential for mediating enhanced TNF effects and thus contribute to the development of pain-related behavior.

Section snippets

Acknowledgements

We are grateful to Jenny Dolkas for expert technical assistance. This study was supported by Deutsche Forschungsgemeinschaft SCHA 924/1-1 (M.S.), NIH NS35630 (L.S.S.) and by the Department of Veterans Affairs.

Cited by (123)

  • 5.23 - Immune System, Pain and Analgesia

    2020, The Senses: A Comprehensive Reference: Volume 1-7, Second Edition
View all citing articles on Scopus
View full text