Elsevier

Neuroscience Letters

Volume 350, Issue 1, 16 October 2003, Pages 56-60
Neuroscience Letters

Despite the general correlation of the serotonin transporter gene regulatory region polymorphism (5-HTTLPR) and platelet serotonin concentration, lower platelet serotonin concentration in migraine patients is independent of the 5-HTTLPR variants

https://doi.org/10.1016/S0304-3940(03)00834-6Get rights and content

Abstract

Platelet serotonin (5-HT) concentrations in a headache-free period during the mid-follicular phase and the serotonin transporter gene regulatory region polymorphism (5-HTTLPR) were measured in female migraine patients without aura (n=64) and healthy controls (n=42). High-pressure liquid chromatography (HPLC) was used to determine the platelet 5-HT concentration and genetic polymorphism was determined by polymerase chain reaction. Significantly lower platelet 5-HT concentrations were found in migraine patients compared to controls. Concerning the 5-HTTLPR polymorphism, the S/S genotype was associated with a significantly higher platelet 5-HT concentration (P=0.027) in the whole study population. This association between the 5-HTTLPR genotypes and platelet 5-HT concentrations was independent of the diagnosis. In addition, the platelet 5-HT concentration was lower in migraineurs in all genotypes (S/S, S/L, L/L). In conclusion, 5-HTTLPR variants may have an effect on the platelet 5-HT concentrations, but the lower 5-HT concentrations in migraine patients seem to be determined by other factors.

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Acknowledgements

This study was supported by the Hungarian Research Fund Grant T022256/1997, T032398/2000 and Postdoctoral PhD Fellowship Program (G.J., R.J.) of the Semmelweis University, Ministry of Culture and Education, Hungary.

References (22)

  • B.D Greenberg et al.

    Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets

    Am. J. Med. Genet.

    (1999)
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