Protein kinase C in the postmortem brain of teenage suicide victims
Section snippets
Acknowledgements
This work was supported by a grant from the National Institute of Mental Health (ROIMH 48153-04 and MH 40279). We acknowledge with thanks the cooperation of Dr. John Smailek, Chief Medical Examiner, and Dr. Dennis Chute, Assistant Medical Examiner, in the collection of brain samples, and Ms. Terri U'Prichard for performing the psychological autopsies.
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2012, Psychiatry ResearchCitation Excerpt :From a pharmacologic perspective, preclinical studies have shown that chronic administration of antidepressants (fluoxetine and desipramine) decreases PKC activity in the cortex and hippocampus of rats (Mann et al., 1995). In teenaged suicide victims PKC in prefrontal (Brodmann Area 8 (BA8) and BA9) brain tissue is reduced in membranal and cytosolic fractions compared with age-matched controls who died of causes other than suicide (Pandey et al., 1997). In a subsequent study of prefrontal and hippocampal postmortem tissue from teenage suicide victims, Pandey et al. found decreased membrane and cytosolic fraction PKC activity, decreased levels in both fractions of the isoenzymes PKC-α, PKC-βI, PKC-βII, PKC-γ, and of their respective m-RNA's (Pandey et al., 2004).
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