d-Aspartate modulates melatonin synthesis in rat pinealocytes
Section snippets
Acknowledgements
H.Y. and S.Y. were supported by Research Fellowship of the Japan Society from Promotion of Science for Young Scientists. This work was supported in part by grants from the Ministry of Education, Science, Sports and Culture of Japan, the Terumo Science Foundation, the Chiba-Geigy Foundation (Japan) for the Promotion of Science, and the Salt Science Research Foundation.
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2022, Journal of Pharmaceutical and Biomedical AnalysisMiR-375-3p mediates reduced pineal function in hypoxia-ischemia brain damage
2021, Experimental NeurologyCitation Excerpt :Glutamate can also inhibit AANAT mRNA expression by combination with metabotropic glutamate receptor type 3 (mGluR3) (Villela et al., 2013; Govitrapong and Ebadi, 1988). Moreover, d-aspartate, another excitatory amino acid, can reduce cAMP levels in the pineal gland in vitro, thus inhibiting AANAT mRNA levels (Ishio et al., 1998). However, miR-375-3p overexpression and OGD/R in pinealocytes induing stronger inhibition on the secretion of melatonin compared to cells only under OGD/R may speak of certain synergism, i.e. the presence of factors other than miR-375-3p involved in the OGD/R effect.
Automatic switching valve system to minimize variation of liquid chromatography-tandem mass spectrometry-based chiral amino acid profiling
2019, Journal of Bioscience and BioengineeringDetection and quantification of D-amino acid residues in peptides and proteins using acid hydrolysis
2018, Biochimica et Biophysica Acta - Proteins and ProteomicsCitation Excerpt :d-Ser is found in the brain, especially in the cerebral cortex and hippocampus, where it modulates neurotransmission upon binding as a coagonist to the Gly site of the N-methyl-d-aspartate (NMDA) receptor, a subtype of the ionotropic glutamate receptor [4,5]. The d-Asp concentration is maintained at high levels in the brain, pineal gland, pituitary gland and testis, and is associated with the regulation of hormonal secretion and steroidogenesis [6–15]. It was recently reported that d-glutamate (d-Glu) is metabolized in the mammalian heart by d-glutamate cyclase that converts d-Glu to 5-oxo-d-proline (5-oxo-d-Pro), although the physiological significance remains unclear at present [16].
Simultaneous analysis of D-alanine, D-aspartic acid, and D-serine using chiral high-performance liquid chromatography-tandem mass spectrometry and its application to the rat plasma and tissues
2015, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :The concentrations of d-Ala were consistent with our previous results (86.4 ± 9.9 nmol/g for anterior pituitary gland, 14.7 ± 2.5 nmol/g for intermediate and posterior pituitary gland, 29.2 ± 5.0 nmol/g for pancreas) [18]. Concerning d-Asp, it was reported to control the synthesis of melatonin in the pineal gland, and promote the secretion of prolactin in the pituitary gland [13–16], and the amounts of d-Asp found in the present paper also agreed with a previous report (3524 ± 263 nmol/g for pineal gland and 80.5 ± 9.0 nmol/g for pituitary gland) [2]. The localization of d-Ser in the brain was first reported by Hashimoto and Nishikawa in 1992 [37] and the functions and the mechanisms to control the d-Ser amounts in the brain have been progressively clarified [38–40].