Mechanical transduction by rat dorsal root ganglion neurons in vitro
Section snippets
Acknowledgements
We thank Dr. Peter Sargent and Dr. Michael Shuster for their comments on the manuscript. This work was supported by National Institutes of Health Grant NS21467.
References (16)
Effects of electrical and mechanical stimulation on two foci of spontaneous activity which develop in primary afferent neurons after peripheral axotomy
Pain
(1984)- et al.
Mechanical stimulation of neurites generates an inward current in putative aortic baroreceptor neurons in vitro
Brain Res.
(1997) - et al.
Co-expression of nociceptor properties in dorsal root ganglion neurons from the adult rat in vitro
Neuroscience
(1996) - et al.
H+-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels
Curr. Opin. Neurobiol.
(1998) - et al.
Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons
J. Cell Biol.
(1998) - et al.
Protons activate a cation conductance in a sub-population of rat dorsal root ganglion neurones
J. Physiol. (Lond.)
(1991) - et al.
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Nature
(1997) - et al.
Response of sensory units with unmyelinated fibres to mechanical, thermal and chemical stimulation of the cat's cornea
J. Physiol. (Lond.)
(1993)
Cited by (192)
The role of mechanosensitive Piezo1 channel in diseases
2022, Progress in Biophysics and Molecular BiologyMaturational Changes in Mouse Cutaneous Touch and Piezo2-Mediated Mechanotransduction
2020, Cell ReportsCitation Excerpt :Piezo2 ion channels have emerged as crucial players for vertebrate mechanotransduction (i.e., the conversion of mechanical to electrical stimuli) involved in physiological and pathological mechanosensation (Coste et al., 2010; Ranade et al., 2014; Ghitani et al., 2017; Murthy et al., 2018; Szczot et al., 2018). By means of so-called whole-cell mechano-clamp (McBride and Hamill, 1992; McCarter et al., 1999; Hao and Delmas, 2011), Piezo2 activity has been measured in cultured DRG neurons of mice aged 4–6 weeks (Poole et al., 2014), 4–8 weeks (Zhang et al., 2019), 6–8 weeks (Ranade et al., 2014), 6–12 weeks (Borbiro et al., 2015), 7–9 weeks (Narayanan et al., 2016), and 9–10 weeks (Narayanan et al., 2018). Also, assessment of spinal circuits relevant for tactile sensitivity has been performed in 2- to 3-week and 4-week-old mice by electrophysiology (Duan et al., 2014; Abraira et al., 2017; Cheng et al., 2017), in 4–5-week-old mice by immunohistology (Abraira et al., 2017), and in spinal cord slices of 8- to 10-week-old mice by calcium imaging (Chen et al., 2014).
5.08 - Molecular Biology of the Nociceptor/Transduction
2020, The Senses: A Comprehensive Reference: Volume 1-7, Second Edition