Elsevier

Neuroscience Letters

Volume 277, Issue 2, 24 December 1999, Pages 134-136
Neuroscience Letters

5-HT2A receptor gene polymorphisms in anorexia nervosa and bulimia nervosa

https://doi.org/10.1016/S0304-3940(99)00859-9Get rights and content

Abstract

To examine the distribution of different polymorphisms in genes of the 5-HT system in patients with anorexia nervosa (AN) and bulimia nervosa (BN), we analyzed the distribution of a polymorphism (−1438G/A) and the presence of known mutations in 5-HT2A and 5-HT2C receptor genes in 168 Italian female patients affected by AN and BN. Patients with AN restricting type (ANr) only, unlike those with AN binge eating/purging type (ANp) and BN purging type (BNp), showed a statistically significant difference in 5-HT2A–1438A/A genotype frequency with respect to controls. With regard to the other polymorphisms, no differences were found in the studied groups with respect to controls. 5-HT2A promoter polymorphism is probably implicated in the susceptibility to eating disorders and its involvement is more significant in ANr, when compared with ANp and BNp.

Cited by (101)

  • Anxiolytic-like effects of leptin on fixed interval responding

    2016, Pharmacology Biochemistry and Behavior
  • Genetic Findings in Anorexia and Bulimia Nervosa

    2010, Progress in Molecular Biology and Translational Science
    Citation Excerpt :

    Association with AN was shown for the A-allele of the promoter polymorphism (− 1438G>A) of the 5-HT2A receptor gene (HTR2A).65 Whereas some of the replication studies confirmed this result,66–69 others did not.70–74 Additionally, an early meta-analysis showed a lack of association.75

  • The possible influence of impulsivity and dietary restraint on associations between serotonin genes and binge eating

    2009, Journal of Psychiatric Research
    Citation Excerpt :

    Most studies of the 5-HT2a receptor gene have examined a single nucleotide polymorphism (SNP) in the promoter region (−1438G/A). Six studies report no association with BN and/or binge eating (Bruce et al., 2005; Enoch et al., 1998; Fuentes et al., 2000; Nacmias et al., 1999; Ricca et al., 2002; Ziegler et al., 1999), while two studies found a higher frequency of the A allele in individuals with BN compared to controls (Ricca et al., 2002, 2004). By contrast, a significant association between BN and the G allele of the −1438G/A SNP has also been reported (Nishiguchi et al., 2001).

View all citing articles on Scopus
View full text