Elsevier

Gene

Volume 250, Issues 1–2, 30 May 2000, Pages 171-180
Gene

Cloning and chromosomal localization of the human BARX2 homeobox protein gene

https://doi.org/10.1016/S0378-1119(00)00169-4Get rights and content
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Abstract

The human BARX2 gene encodes a homeodomain-containing protein of 254 amino acids, which binds optimally to the DNA consensus sequence YYTAATGRTTTTY. BARX2 is highly expressed in adult salivary gland and is expressed at lower levels in other tissues, including mammary gland, kidney, and placenta. The BARX2 gene consists of four exons, and is located on human chromosome 11q25. This chromosomal location is within the minimal deletion region for Jacobsen syndrome, a syndrome including craniosynostosis and other developmental abnormalities. This chromosomal location, along with the reported expression of murine barx2 in craniofacial development, suggests that BARX2 may be causally involved in the craniofacial abnormalities in Jacobsen syndrome.

Keywords

Chromosome 11
Jacobsen syndrome
Medullary thyroid carcinoma
Salivary gland

Abbreviations

CT, calcitonin
IPTG, isopropyl-β-D-thiogalactopyranoside
MTC, medullary thyroid carcinoma
PAC, P1-derived artificial chromosome
RRE, ras/raf responsive element
YAC, yeast artificial chromosome

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