Elsevier

Gene

Volume 205, Issues 1–2, 31 December 1997, Pages 177-182
Gene

Mobile elements inserted in the distant past have taken on important functions

https://doi.org/10.1016/S0378-1119(97)00399-5Get rights and content

Abstract

Current evidence on the long-term evolutionary effect of insertion of sequence elements is reviewed. There are three criteria for inclusion of an example: (i) the element was inserted far in the past and thus the event is not a transient mutation; (ii) the element is a member of a large group of similar sequences; (iii) the element now serves a useful function. There are 21 examples from Drosophila, sea urchin, human and mouse genomes that meet these criteria. Taken together, these examples show that the insertion of sequence elements in the genome has been a significant source of regulatory variation in evolution.

References (39)

  • M. Nemer et al.

    Spatial regulation of SpMTA metallothionein gene expression in sea urchin embryos by a regulatory cassette in intron 1

    Mech. Dev.

    (1995)
  • J. Norris et al.

    Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers

    J. Biol. Chem.

    (1995)
  • F.J. Piedrafita et al.

    An Alu element in the myeloperoxidase promoter contains a composite SPl-thyroid hormone-retinoic acid response element

    J. Biol. Chem.

    (1996)
  • S.R. Wessler

    Turned on by stress

    Curr. Biol.

    (1996)
  • R.J. Britten et al.

    Gene regulation for higher cells: a theory

    Science

    (1969)
  • R.J. Britten et al.

    Repetitive and non-repetitive DNA sequences and a speculation on the origins of evolutionary novelty

    Q. Rev. Biol.

    (1971)
  • F.J. Calzone et al.

    Gene regulatory factors of the sea urchin embryo I. Purification by affinity chromatography and cloning of P3A2, a novel DNA-binding protein

    Development

    (1991)
  • O.N. Danilevskaya et al.

    Drosophila telomere transposon HeT-A produces a transcript with tightly bound protein

  • D. Ding et al.

    Spatially regulated expression of retrovirus-like transposons during Drosophila melanogaster embryogenesis

    Genet. Res.

    (1994)
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