Suppression of microsomal cytochrome P450-dependent monooxygenases and mitochondrial oxidative phosphorylation by fullerenol, a polyhydroxylated fullerene C60
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2017, European Journal of PharmacologyCitation Excerpt :Despite being considered a safe anaesthetic, cases of hepatotoxicity after propofol anaesthesia have been reported (Anand et al., 2001; Asai et al., 2013; Nguyen and Borurn, 2009; Polo-Romero et al., 2008) which can be manifested during short or long term sedation (Kneiseler et al., 2010). Notwithstanding, it is known from the literature that propofol interferes with levels of hepatic enzymes (Granados Llamas et al., 1999; Tiainen et al., 1995) and with cytochrome P450-dependent monooxygenases system (Baker et al., 1993; Chen et al., 1995), which is responsible for the oxidation-reduction reactions of xenobiotics in the liver (Ueng et al., 1997). This system is also responsible, in part, for the fatty acid oxidation that occurs mainly in mitochondria, peroxisomes or microsomes (Reddy and Hashimoto, 2001).
Fullerenol C<inf>60</inf>(OH)<inf>24</inf> increases ion permeability of lipid membranes in a pH-dependent manner
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