Original ArticlesThe importance of inflammatory mechanisms in alzheimer disease
Section snippets
Acknowledgements
Our research on Alzheimer disease is supported by grants from the Alzheimer Society of B.C., the Jack Brown and Family A.D. Research Fund, and donations from individual British Columbians.
References (22)
- et al.
Delayed onset of Alzheimer’s disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs
Neurobiol. Aging
(1995) - et al.
Prevention of NSAID-induced gastric ulcer with misoprostolMulticentre, double-blind, placebo-controlled trial
Lancet
(1988) - et al.
Activation of macrophages by Alzheimer β amyloid peptide
Biochem. Biophys. Res. Commun.
(1994) - et al.
The inflammatory system of brainImplications for therapy of Alzheimer and other neurodegenerative disorders
Brain. Res. Rev.
(1995) - et al.
Neuronal expression of mRNAs for complement proteins of the classical pathway in Alzheimer brain
Brain Res.
(1997) - et al.
Chromogranin A triggers a phenotypic transformation and the generation of nitric oxide in brain microglial cells
Neuroscience
(1996) - et al.
Neurons express proteins of the classical complement pathway in Alzheimer disease
Brain Res.
(1997) - et al.
Molecular and cellular characterization of the membrane attack complex, C5b-9, in Alzheimer’s disease
Neurobiol. Aging
(1997) - et al.
Inverse association of anti-inflammatory treatments and Alzheimer’s disease
Neurology
(1994) - et al.
NSAIDs and cognition in Alzheimer’s disease
Neurology
(1996)
Rheumatoid arthritis and senile dementia of the Alzheimer’s type
Br. J. Rheumatol.
Cited by (311)
Association between serum lipid levels and lower-extremity functions in older adults with and without Alzheimer's dementia in South Korea: A cross-sectional analysis
2023, Archives of Gerontology and GeriatricsVitamin D and inflammatory cytokines association in mild cognitive impaired subjects
2023, Neuroscience LettersClinical role of oxides in Neuropsychiatric and Neurodegenerative disorders
2023, Oxides for Medical ApplicationsMetformin in Alzheimer's disease: An overview of potential mechanisms, preclinical and clinical findings
2022, Biochemical PharmacologyCitation Excerpt :Generally, according to the mentioned studies, the effect of metformin on tau phosphorylation is controversial and more studies are needed to clarify the accurate effect of metformin on this process. One of the main characteristic pathological features of AD is neuroinflammation [69]. Initially, the use of NSAID drugs was recognized as reducing the risk of AD by 50% [70], and finally, their protective effects against Aβ-induced neurotoxicity were proven in various culture and animal models [71,72].
C-reactive protein and risk of Alzheimer's disease
2022, Neurobiology of AgingCitation Excerpt :CRP can activate the classic complement system, causing cell lysis and phagocytosis of cell fragments (McGeer and McGeer, 1998). For AD, activation of complement system could not only ruin damaged neurons, but also lead to bystander lysis of healthy cells (McGeer and McGeer, 1998). Moreover, activators of the complement pathway such as CRP, had also been observed in AD lesions (Yasojima et al., 2000).