Endothelial progenitor cell-seeded grafts: Rash and riskyLes greffes endothéliales de cellules souches : Téméraires et risquées
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Cited by (25)
Device thrombosis and pre-clinical blood flow models for assessing antithrombogenic efficacy of drug-device combinations
2017, Advanced Drug Delivery ReviewsCitation Excerpt :In addition to synthetic modifications of device surfaces with anticoagulants and antiplatelet agents, in-vitro seeding of endothelial cell types onto biomaterials, especially for vascular grafts, has been attempted to present blood with a naturally non-thrombogenic surface [77]. While intuitively attractive in theory, providing the appropriate basal layer on the device surface for the endothelial cells to securely adhere, grow, express adequate antithrombogenic properties, and endure high shear conditions has proven to be difficult [78]. Despite some recent success with these challenges, the time it takes to culture the cells on the device in a sterile environment and qualify its function reliably makes this an expensive option with a dubious cost–benefit ratio in an increasingly cost sensitive healthcare environment.
Improved endothelialization and reduced thrombosis by coating a synthetic vascular graft with fibronectin and stem cell homing factor SDF-1α
2012, Acta BiomaterialiaCitation Excerpt :A concept to overcome this problem is in vitro cell seeding of the whole graft with progenitor cells before implantation. Although experimental studies on prosthetic graft seeding using EPC have shown excellent results on graft endothelialization, none of these studies reported favorable effects on the more clinically relevant endpoints such as intimal hyperplasia or graft patency [5,6,8,10–12]. Other studies, focusing rather on such a reduction of neointima formation, were based on pharmacological interventions.
Bio artificial surfaces - Blood surface interaction
2011, Materials Science and Engineering CCitation Excerpt :After seeding, grafts were left in culture medium for another week to allow the maturation of the cytoskeleton of the endothelial cells and thus increase their shear stress resistance [7–11] (Fig. 4). Although different clinical studies [12–16] could demonstrate significantly improved clinical patency rates, this method could not be established because of its time-consuming and costly procedure. An alternative way to bypass or replace vascular stenosis is to splint the vessel.
Multilayered blow-spun vascular prostheses with luminal surfaces in Nano/Micro range: the influence on endothelial cell and platelet adhesion
2023, Journal of Biological EngineeringIn vivo endothelialization and neointimal hyperplasia assessment after angioplasty of sheep carotid artery with a novel polycarbonate polyurethane patch
2019, Journal of Biomaterials Applications