Original articleSurgical treatment of severe autistic regression in childhood epilepsy
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Cited by (78)
Social cognition and psychopathology in childhood and adolescence
2019, Epilepsy and BehaviorCitation Excerpt :Symptomatic WS is often characterized by abnormalities in the temporal lobe, and children with WS and autistic or hyperkinetic behavior are significantly more likely to show temporal lobe dysfunction [71]. Temporal lobe lesions are further associated with poorer long-term neurodevelopmental outcomes and ASD [72–75]. Infantile spasms in the context of tuberous sclerosis present a particular risk of comorbid autism, with prevalence as high as 70% [76].
Children with autism spectrum disorders and drug-resistant epilepsy can benefit from epilepsy surgery
2018, Epilepsy and BehaviorCitation Excerpt :In this retrospective study, 7 subjects had ASD, and all had seizures after epilepsy surgery [11]. However, in another report on 2 children who had surgical resection with severe autistic regression, there was improvement in seizure control and development [12]. Gillberg et al. also reported improvements in seizures and autistic features in 2 pre-adolescent males with epilepsy and autism [13].
Epilepsy Associated with ASD and Intellectual Disability
2016, Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual DisabilityInterest of dedicated neurobehavioral units in management of acute behavioral crises in psychiatric inpatients with autism spectrum disorder
2015, Neuropsychiatrie de l'Enfance et de l'AdolescenceInterictal epileptiform activity and autism
2015, Epilepsy and BehaviorCitation Excerpt :The authors reported a case [80] of a child with autism and IEDs, without definite clinical seizures, who was treated with the modified Atkins diet and had complete suppression of his spikes, associated with improved speech and decreased hyperactivity. Finally, epilepsy surgery was also reported to cause variable cognitive and behavioral improvements in individuals with autistic regression either with [69–71] or without [45] intractable epilepsy. Unfortunately, there are no controlled clinical trials investigating the effect of treating epileptiform activity specifically in patients with autism.