Neuron
Volume 40, Issue 2, 9 October 2003, Pages 297-318
Journal home page for Neuron

Review
Polarized Domains of Myelinated Axons

https://doi.org/10.1016/S0896-6273(03)00628-7Get rights and content
Under an Elsevier user license
open archive

Abstract

The entire length of myelinated axons is organized into a series of polarized domains that center around nodes of Ranvier. These domains, which are crucial for normal saltatory conduction, consist of distinct multiprotein complexes of cell adhesion molecules, ion channels, and scaffolding molecules; they also differ in their diameter, organelle content, and rates of axonal transport. Juxtacrine signals from myelinating glia direct their sequential assembly. The composition, mechanisms of assembly, and function of these molecular domains will be reviewed. I also discuss similarities of this domain organization to that of polarized epithelia and present emerging evidence that disorders of domain organization and function contribute to the axonopathies of myelin and other neurologic disorders.

Cited by (0)