Research letterFolate and chemoprevention of colorectal cancer: is 5-methyl-tetrahydrofolate an active antiproliferative agent in folate-treated colon-cancer cells?
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Methionine restriction inhibits chemically-induced malignant transformation in the BALB/c 3T3 cell transformation assay
2016, Food and Chemical ToxicologyCitation Excerpt :While a study conducted in our laboratory showed that supplementation of supraphysiological (25 times higher) FA levels resulted in an increased number of ACF's in F344 rats (Nicken et al., 2012), an increased FA concentration in the cell culture medium did neither significantly enhance the cell transformation rate nor exert a statistically significant influence on the CFE. This might be explained, as in the case of MET, by the induction of a cell cycle arrest and other antiproliferative effects, as has been shown by Akoglu et al. (2001) in colon cancer cells receiving up to 22 μM FA. However, it should be pointed out that other studies describe a dose-dependent increase of cellular proliferation in neurosphere cultures starting at similar concentrations as used herein (18 μM; Liu et al., 2010).
Enhanced one-carbon flux towards DNA methylation: Effect of dietary methyl supplements against γ-radiation-induced epigenetic modifications
2010, Chemico-Biological InteractionsCitation Excerpt :As concentrations of purine/pyrimidine decrease, biochemical repair mechanisms may decrease the conversion of 5,10-methylenetetrahydrofolate (5,10-methyleneTHF) to 5-methyltetrahydrofolate (5-methyl THF). This is an irreversible reaction, and thereby leads to less folate availability for DNA methylation [7]. Hence, DNA methylation level can be altered by intermediary moiety 5-methyl THF, which is needed to methylate homocysteine to methionine.
Chapter 2 Mathematical Models of Folate-Mediated One-Carbon Metabolism
2008, Vitamins and HormonesCitation Excerpt :Thus, a prediction of the model is that a high intracellular folate level can have the same effect as a folate deficiency. This prediction of the model is now supported by a variety of clinical and experimental data that show that high doses of folate can have detrimental effects (Akoglu et al., 2001; Czeizel, 2004; Morris et al., 2005; Sunder‐Plassman et al., 2000; Troen et al., 2006). We then expanded the model of Reed et al. (2006) to include compartmentation of the folate cycle between cytosol and mitochondria (Nijhout et al., 2007a).
Folates as antioxidants
2007, Food ChemistryTumor quantification of several fluoropyrimidines resistance gene expression with a unique quantitative RT-PCR method. Implications for pretherapeutic determination of tumor resistance phenotype
2006, Cancer LettersCitation Excerpt :Indeed, numerous studies suggested that low folate intake increased carcinogenesis [39,40]. Moreover DHF and methyl-THF had an antiproliferative effect in human colon cancer cell line in vitro [41,42]. At last, Levy and coll.