Oxidative reactions and schizophrenia: A review-discussion
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2017, Neuroscience and Biobehavioral ReviewsCitation Excerpt :It is defined as an imbalance in the pro-oxidant/antioxidant balance in favor of the former, leading to potential damage (Bo et al., 2011). The imbalance between reactive oxygen species (ROS) generative and scavenging activities in the cell subsequently leads to ROS accumulation (Chaudhari et al., 2014; Smythies, 1997). Mitochondria, ER, and peroxisomes are the three major, vital intracellular organelles generating ROS.
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2016, Psychiatry Research - NeuroimagingProtective effects of atypical antipsychotic drugs against MPP<sup>+</sup>-induced oxidative stress in PC12 cells
2011, Neuroscience ResearchCitation Excerpt :The etiology of schizophrenia remains unclear. A good deal of evidence suggests that oxidative stress may play an important role in the pathophysiology of schizophrenia (Smythies, 1997; Fenton et al., 2000). Oxidative stress occurs due to an imbalance between levels of free radical production and the efficiency of the antioxidant enzyme system to neutralize and eliminate reactive oxygen species (ROS).
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