Elsevier

Schizophrenia Research

Volume 27, Issues 2–3, 30 October 1997, Pages 143-156
Schizophrenia Research

Review of functional magnetic resonance imaging in schizophrenia

https://doi.org/10.1016/S0920-9964(97)00063-7Get rights and content

Abstract

Functional magnetic resonance imaging (fMRI) holds geat promise for assessing temporal changes in brain activity using various challenge paradigms. In this report, we review the 14 studies (eight of them abstracts) that comprise the fMRI literature available to date relating to schizophrenia. Twelve of the 14 investigations examined changes in blood-oxygen-level-dependent (BOLD) contrast; two examined blood volume. Eight of the 12 BOLD studies relied on lower-order cognitive processing to measure activation (involving sensory or motor areas), whereas four used higher-order tasks (work production, auditory processing, and subspan word recall involving multiple brain areas). Although the variability in tasks used, brain regions studied, imaging methods used, patient characteristics reported, and methods of reporting significance precluded a full meta-analysis, we re-analyzed these published data to compute effect sizes. In most studies, resting blood volume and BOLD changes, regardless of the complexity of the cognitive task, appeared to differ between patients with schizophrenia and control subjects.

References (42)

  • BiswalB. et al.

    Functional connectivity in the motor cortex of resting human brain using echo-planar MRI

    Magn. Reson. Med.

    (1995)
  • BuckleyP.F. et al.

    Functional magnetic resonance imaging in schizophrenia

  • BurkhardtC. et al.

    Neuroleptic medications inhibit complex I of the electron transport chain

    Ann. Neurol.

    (1993)
  • ChuaS.E. et al.

    Schizophrenia—a brain disease?

    A critical review of structural and functional cerebral abnormality in the disorder

    Br. J. Psychiatry

    (1995)
  • CohenB.M. et al.

    Abnormalities of regional distribution of cerebral vasculature in schizophrenia detected by dynamic susceptibility contrast MRI

    Am. J. Psychiatry

    (1995)
  • CohenJ.

    Statistical Power Analysis for the Behavioral Sciences

    (1988)
  • CohenJ.

    A power primer

    Psychol. Bull.

    (1992)
  • CoxR.W.

    Medical College of Wisconsin Analysis of Functional NeuroImages

    (1995)
  • DavidA.S. et al.

    Schizophrenic hallucinations attenuate activation in the superior temporal lobe

  • DavidA.S. et al.

    Auditory hallucinations inhibit exogenous activation of auditory association cortex

    NeuroReport

    (1996)
  • FristonK.J. et al.

    Comparing functional (PET) images: the assessment of significant change

    J. Cereb. Blood Flow Metab.

    (1991)
  • Cited by (0)

    View full text