The role of the macrophage in immune regulation

doi:10.1016/S0923-2494(99)80039-X

Research in Immunology

Volume 149, Issues 7–8, 10 September 1998, Pages 685-688

https://doi.org/10.1016/S0923-2494(99)80039-X Get rights and content

Summary

The macrophage plays an important role in both the innate and acquired (humoral and cellular) immune responses. Their specialized derivatives, the dendritic cells (DCs), are uniquely potent in induction of naive T and B lymphocytes, whereas macrophages influence a range of immune responses by antigen recognition, capture, clearance and transport. They recruit haemopoietic cells to local sites of inflammation and immunity and regulate their activities. We have used various myeloid-restricted membrane antigens and receptors as markers and functional contributors to these activities, and briefly review their role in immune regulation in vivo and in vitro.

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Citation Excerpt :
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The role of the macrophage in immune regulation

Summary

J. Biol. Chem.

Cell

J. Biol. Chem.

Trends Biochem. Sci.

Adv. Immunol.

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

Nature

Sialoadhesin binds preferentially to cells of the granulocytic lineage

J. Clin. Investigat.

Sialoadhesin, a macrophage-specific adhesion molecule for haemopoietic cells with 17 immunoglobulin-like domains

Embo J.

M-CSF selectively enhances macrophage scavenger receptor expression and function

J. Exp. Med.

The type I macrophage scavenger receptor binds to gram-positive bacteria and recognises lipoteichoic acid

PNAS

Divalent cation-independent macrophage adhesion inhibited by monoclonal antibody to murine scavenger receptor

Nature