The role of the macrophage in immune regulation
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2022, Food BioscienceCitation Excerpt :This suggests that a decrease in macrophage stimulation can eventually have a significant impact on the anti-cancer effect of BF–I. Since the immune system is a huge network in which various factors are intricately intertwined, cytokine secretion by macrophages alone cannot fully explain the anti-cancer effect of BF–I. Nevertheless, it is clear that the inactivation of initiators, such as macrophages, implies a decrease in the overall immune response (Gordon, 1998). In a previous study, we reported that the anti-cancer effect of BF–I is closely related to its immune activity.
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