Compliance to combination antiretroviral therapy in HIV-1 infected children
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Cited by (19)
Design and challenges of a large HIV prevention clinical study on mother-to-child transmission: ANRS 12397 PROMISE-EPI study in Zambia and Burkina Faso
2021, Contemporary Clinical TrialsCitation Excerpt :Zidovudine/lamivudine is a dispersible tablet to be taken twice daily and nevirapine is a syrup to be taken once daily. Many variables influence adherence to a single-drug regimen or to a more complex regimen such as formulation of drugs, number of tablet/syrup, schedule of administration, palatability (43). Suboptimal observance may increase the risk of HIV acquisition, including acquisition of a resistant virus.
Adherence to antiretroviral therapy of Brazilian HIV-infected children and their caregivers
2016, Brazilian Journal of Infectious DiseasesCitation Excerpt :In developing countries caregiver reports are commonly employed to assess children's adherence, but there are no gold standard methods for measuring it.15–18 Results from seven studies that used caregivers reports, showed that 34–100% of caregivers reported 100% adherence and some of them showed that caregivers generally overestimate adherence in comparison with other methods.5,6,19–23 Other results on caregiver characteristics indicated that children are more adherent if they receive their medications from foster parents rather than the biological ones, or other relatives.7,24
Determination of formulation factors that affect oral medicines acceptability in a domiciliary paediatric population
2015, International Journal of PharmaceuticsCitation Excerpt :There is a paucity of studies investigating barriers to medicines administration arising from oral formulations (particularly those related to organoleptic and physical properties) in children with chronic conditions. Those studies reported previously are limited to specific disease groups, e.g. antiretroviral medicines in Human Immunodeficiency Virus (HIV) (Boni et al., 2000; Gibb et al., 2003; Goode et al., 2003; Marhefka et al., 2004; Pontali et al., 2001; Wrubel et al., 2005). Further studies compare the acceptance and flavour preferences of a spectrum of drugs from one class (e.g. antibiotics) using a “one-off” taste test method, commonly with the aid of a visual analogue scale (VAS) most often in healthy children or adults (Bagger-Sjöbäck and Bondesson, 1989; Chan et al., 1997; Cohen et al., 2009; El-Chaar et al., 1996; Samulak et al., 1996; Toscani et al., 2000).
Evaluation of a program for assessing adherence to antiretroviral treatment
2011, Anales de PediatriaEvidence of acceptability of oral paediatric medicines: a review
2017, Journal of Pharmacy and PharmacologyThe need for pediatric formulations to treat children with HIV
2016, AIDS Research and Treatment