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Evaluation of a synergistic combination between the non-antibiotic microbicides diclofenac and trifluoperazine

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Cited by (11)

  • Activity of diclofenac used alone and in combination with streptomycin against Mycobacterium tuberculosis in mice

    2007, International Journal of Antimicrobial Agents
    Citation Excerpt :

    The anti-inflammatory drug diclofenac sodium (DCL) possesses powerful biocidal activity towards Gram-positive and Gram-negative bacteria [2,3] and mycobacteria [4]. It was synergistic with streptomycin (STM) against Mycobacterium smegmatis [5] and strains of Escherichia coli and Staphylococcus aureus, and also with a non-antibiotic trifluoperazine against some Gram-positive and Gram-negative bacteria [6,7]. Prolonged and widespread use of STM as monotherapy in tuberculosis has resulted in an average of 1 in 108 tubercle bacilli being resistant to STM at 10–100 μg/mL.

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