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Retinitis pigmentosa and schizophrenia

Published online by Cambridge University Press:  16 April 2020

C McDonald ,
P Kenna  and
T Larkin
C McDonald
Affiliation:
Institute of Psychiatry, Department of Psychological Medicine, de Crespigny Park, London SE5 8AF UK St John of God Hospital, Stillorgan, Co Dublin, Ireland
P Kenna
Affiliation:
Department of Genetics, Trinity College, Dublin 2
T Larkin
Affiliation:
St John of God Hospital, Stillorgan, Co Dublin, Ireland
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Summary

There have been previous suggestions in the literature of a link between schizophrenia and retinitis pigmentosa (RP) or its associated syndromes. In this article, we describe two cases of schizophrenía and two cases of delusional disorder occurring in patients with RP. We explore possible reasons for an association between RP and schizophrenia including shared genetic predisposition, sensory deprivation, coarse brain disease and retinoid dysregulation. Awareness of an association may help to direct future research into the aetiology of these disorders, especially in the areas of neurochemistry and medical genetics.

Keywords

retinitis pigmentosaUsher syndromepsychosis, schizophrenia
Type
Case Report
Information
European Psychiatry , Volume 13 , Issue 8 , December 1998 , pp. 423 - 426
Copyright
Copyright © Elsevier, Paris 1998

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