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Overdose with sustained-release lithium preparations

Published online by Cambridge University Press:  16 April 2020

B Astruc ,
P Petit  and
M Abbar
B Astruc
Affiliation:
Department of Psychiatry, Caremeau Hospital, 30000Nîmes
P Petit
Affiliation:
Department of Psychopharmacology, La Colombière Hospital, 34000Montpellier, France
M Abbar
Affiliation:
Department of Psychiatry, Caremeau Hospital, 30000Nîmes
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Summary

Acute lithium intoxication is potentially lethal. Compared to conventional lithium preparations, sustained-release lithium formulations present specific problems for medical practice in the case of overdose. We report a case of intoxication with 8000 mg of sustained-release lithium carbonate preparation (Teralithe 400 LP®). Twenty-five hours after the ingestion, the patient was still asymptomatic, despite a serum level in the toxic range. After comparison of this case with reports found in the Medline database, we consider the clinical management of such cases.

Keywords

overdosesuicide attemptsustained-release lithium preparation
Type
Case Reports
Information
European Psychiatry , Volume 14 , Issue 3 , June 1999 , pp. 172 - 174
Copyright
Copyright © European Psychiatric Association 1999

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References

Achong, MR, Fernandez, PG, McLeod, PJFatal self poisoning with lithium carbonate. Can Med Assoc J 1975 ; 112 : 868–870.Google ScholarPubMed
Amdissen, A, Sjogren, JLithium absorption from sustained release tablets. Acta Pharm Nord 1968 ; 5 : 465–472.Google Scholar
Bosse, GM, Arnold, TCOverdose with sustained-release lithium preparations. J Emerg M 1992 ; 10 : 719–721.CrossRefGoogle ScholarPubMed
Buckley, NA, Dawson, AH, Reith, DAControlled release drugs in overdose Clinical considerations. Drug Saf 1995 ; 12 : 73–84.CrossRefGoogle ScholarPubMed
Friedberg, RC, Spyker, DA, Herold, DAMassive overdoses with sustained-release lithium carbonate preparations. Clin Chem 1991 ; 37 : 1205–1209.CrossRefGoogle ScholarPubMed
Goldfrank, LR, Osborn, H, Weisman, RSLithium. In: Goldfrank's toxicologic emergency 4th 1990 Norwalk, Connecticut: Appleton and Lange 427–431.Google Scholar
Michona, A, Spyker, DAAcute overdose with sustained release formulations Perspectives in treatment. Med Toxicol 1986 ; 1 : 300–307.Google Scholar
Okusa, MD, Crystal, LJClinical manifestations and management of acute lithium intoxication. Am J M 1994 ; 97 : 383–389.CrossRefGoogle ScholarPubMed
Schou, M, Amdissen, A, Trap-Jensen, JLithium poisoning. Am J Psychiatry 1968 ; 125 : 520–527.CrossRefGoogle ScholarPubMed
Smith, SWOverdose with sustained-release lithium preparation, letter and comment. J Emerg M 1993 ; 11 : 759–760.CrossRefGoogle Scholar
Tilkian, AG, Schroeder, JS, Kao, JJ, Hultgren, HNThe cardiovascular effects of lithium in man: a review of the literature. Am J M 1976 ; 61 : 665–670.CrossRefGoogle ScholarPubMed
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