Localization of cathepsin D in rat ocular tissues. An immunohistochemical study
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Cited by (19)
Cellular and molecular mechanisms of age-related macular degeneration: From impaired autophagy to neovascularization
2013, International Journal of Biochemistry and Cell BiologyCitation Excerpt :In the RPE cells, cathepsins A, D, E and S have been characterized (Im and Kazlauskas, 2007). Cathepsin D plays an important role in the degradation of rod outer segments and rhodopsin into glycopeptides. (el-Hifnawi, 1995). Interestingly, cathepsin D-deficient mice have been shown to develop postnatal retinal atrophy and suffer an increased incidence of apoptosis in the outer and inner nuclear layers (Koike et al., 2003).
The role of cathepsins in ocular physiology and pathology
2007, Experimental Eye ResearchCitation Excerpt :Although the potential to use cathepsin inhibitors to prevent and/or manage ocular diseases is as yet unexplored, promising results from numerous clinical studies in other diseases suggest that targeting cathepsin activity will be a useful approach to prevent and/or cure ocular diseases. Cathepsin D found in the lysosome of retinal pigment epithelium cell plays a main role in degradation of the phagocytosed photoreceptor during their renewal process (el-Hifnawi, 1995). Cathepsin D degrades rod outer segments and rhodopsin into glycopeptides.
Legacy of the RCS rat: Impact of a seminal study on retinal cell biology and retinal degenerative diseases
2001, Progress in Brain ResearchGene expression of proteases and protease inhibitors in the human ciliary epithelium and ODM-2 cells
1997, Experimental Eye ResearchDistribution of cathepsin D in human ocular tissue: An immunohistochemical study
1995, Annals of Anatomy
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