Omega-3 fatty acids and bipolar disorder: a review

https://doi.org/10.1016/S0952-3278(99)80008-8Get rights and content

Abstract

The important role of the omega-3 fatty acids in the pathophysiology and treatment of bipolar disorder is now supported by a substantial body of indirect and direct evidence. This paper will describe the clinical and pharmacological features of bipolar disorder, review the available data regarding omega-3 fatty acids in bipolar disorder and provide recommendations for future research.

References (46)

  • Z. Cohen et al.

    Microalgae as a source of omega-3 fatty acids

    World Rev Nutr Diet

    (1995)
  • J.R. Hibbeln

    Fish consumption and major depression

    Lancet

    (1998)
  • M.M. Weissman et al.

    Cross-national epidemiology of major depression and bipolar disorder

    JAMA

    (1996)
  • L.G. Cleland et al.

    Clinical and biochemical effects of dietary fish oil supplements in rheumatoid arthritis

    J Rheumatol

    (1988)
  • F.K. Goodwin et al.
    (1990)
  • M.J. Gitlin et al.

    Relapse and impairment in bipolar disorder

    Am J Psychiatry

    (1995)
  • American Psychiatric Association
  • M.P. Freeman et al.

    Mood stabilizer combinations: a review of safety and efficacy

    Am J Psychiatry

    (1998)
  • A.J. Gelenberg

    New anticonvulsants in bipolar and other psychiatric disorders

    Biological Therapies in Psychiatry

    (1997)
  • C.L. Bowden et al.

    Efficacy of divaluroex vs. lithium and placebo in the treatment of mania

    JAMA

    (1994)
  • J.R. Calabrese et al.

    Spectrum of efficacy of valproate in 55 patients with rapid-cycling bipolar disorder

    Am J Psychiatry

    (1990)
  • P.A. Keck et al.

    Valproate oral loading in the treatment of acute mania

    J Clin Psychiatry

    (1993)
  • J.I.T. Isojarvi et al.

    Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy

    NEJM

    (1993)
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