The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation

doi:10.1016/S0952-7915(98)80175-1

Current Opinion in Immunology

Volume 10, Issue 3, June 1998, Pages 353-359

https://doi.org/10.1016/S0952-7915(98)80175-1 Get rights and content

Abstract

The activation of B and T cells by a wide range of stimuli can rapidly induce specific gene expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear factor-κB (NF-κB) transcription factors which are normally resident in the cytoplasm. Recent findings highlight the crucial roles of specific Rel/NF-κB family members in the processes of cell division, apoptosis and differentiation that accompany lymphocyte activation.

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The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation

Abstract

Immunity

Immunity

J Immunol

Science

Proc Natl Acad Sci USA

Immunity

Immunity

Science

Function and activation of NF-κB in the immune system

Annu Rev Immunol

Rel/NF-κB/lκB family: intimate tails of association and dissociation

Genes Dev

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

Genes Dev

NF-κB RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses

J Exp Med

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

Cell

Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-κB2

J Exp Med

Multifocal defects in immune responses in RelB-deficient mice

J Immunol

Expression of relB is required for development of thymic medulla and dendritic cells

Nature

p50-NF-κB complexes partially compensate for the absence of RelB: severely increased pathology in p50−/−relB−/− double-knockout mice

J Exp Med

Requirement for NF-κB in osteoclast and B-cell development

Genes Dev

Abnormal T lymphocyte development induced by targeted overexpression of IκBα

J Immunol

Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-κB

J Exp Med

The subunit composition of NF-κB complexes changes during B-cell development

Cell Growth Differ

B lymphocytes diferentially use the Rel and NF-κB1 transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells

J Exp Med

Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator

Science

Apoptosis: Activate or die?

Curr Biol

p50-NF-κB complexes partially compensate for the absence of RelB: severely increased pathology in p50^−/−relB^−/− double-knockout mice