Reviews: current topic
Nutritional approaches to combat oxidative stress in Alzheimer’s disease

https://doi.org/10.1016/S0955-2863(02)00205-XGet rights and content

Abstract

Alzheimer’s disease (AD) brains are characterized by extensive oxidative stress. Additionally, large depositions of amyloid β-peptide (Aβ) are observed, and many researchers opine that Aβ is central to the pathogenesis of AD. Our laboratory combined these two observations in a comprehensive model for neurodegeneration in AD brains centered around Aβ-induced oxidative stress. Given the oxidative stress in AD and its potentially important role in neurodegeneration, considerable research has been conducted on the use of antioxidants to slow or reverse the pathology and course of AD. One source of antioxidants is the diet. This review examines the literature of the effects of endogenous and exogenous, nutritionally-derived antioxidants in relation to AD. In particular, studies of glutathione and other SH-containing antioxidants, vitamins, and polyphenolic compounds and their use in AD and modulation of Aβ-induced oxidative stress and neurotoxicity are reviewed.

Keywords

Alzheimer’s disease
Antioxidants
Glutathione
Polyphenols
Vitamins
Oxidative stress
Amyloid beta-peptide
Cellular response genes

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