Genetics of infectious disease resistance

https://doi.org/10.1016/S0959-437X(96)80013-XGet rights and content

Abstract

The identification of large numbers of candidate genes and the introduction of methodologies for whole-genome screening have provided new opportunities for elucidating the molecular basis of variable susceptibility to major infectious diseases. 12 genes have been implicated in variable susceptibility to malaria and susceptibility/resistance genes for several other infectious diseases are beginning to be identified. Recent work suggests that large-scale family linkage and population association studies will be a more successful route to human disease genes than extrapolation from mouse models of infection.

References (51)

  • C Tournamille et al.

    Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals

    Nat Genet

    (1995)
  • AVS Hill et al.

    Common west African HLA antigens are associated with protection from severe malaria

    Nature

    (1991)
  • AVS Hill et al.

    Human leukocyte antigens and natural selection by malaria

    Philos Trans R Soc Lond B Biol Sci

    (1994)
  • W McGuire et al.

    Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria

    Nature

    (1994)
  • M Cabrera et al.

    Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis

    J Exp Med

    (1995)
  • CG Meyer et al.

    HLA-D alleles associated with generalized disease, localized disease, and putative immunity in Onchocerca volvulus infection

    Proc Natl Acad Sci USA

    (1994)
  • M Yazdanbaksh et al.

    HLA and elephantiasis in lymphatic filariasis

    Hum Immunol

    (1995)
  • WW Stead et al.

    Racial differences in susceptibility to infection by Mycobacterium tuberculosis

    N Engl J Med

    (1990)
  • R Rani et al.

    Study of HLA class II alleles by PCR oligotyping in leprosy patients from north India

    Tissue Antigens

    (1993)
  • JR Todd et al.

    Human leukocyte antigen and leprosy: study in northern Louisiana and review

    Rev Infect Dis

    (1990)
  • TM Lin et al.

    Hepatitis B virus markers in Chinese twins

    Anticancer Res

    (1989)
  • A Almarri et al.

    HLA and hepatitis B infection

    Lancet

    (1994)
  • MR Thursz et al.

    Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia

    N Engl J Med

    (1995)
  • BL Kroner et al.

    Concordance of human leukocyte antigen haplotype-sharing, CD4 decline and AIDS in hemophilic siblings. Multicenter Hemophilia Cohort and Hemophilia Growth and Development Studies

    AIDS

    (1995)
  • S Rowland-Jones et al.

    HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women

    Nat Med

    (1995)

    • Cited by (0)

    View full text
    Copyright © 1996 Published by Elsevier Ltd.