Bone morphogenetic proteins in development

https://doi.org/10.1016/S0959-437X(96)80064-5Get rights and content

Abstract

The bone morphogenetic proteins (BMPs) constitute a large family of cytokines related to members of the transforming growth factor-β superfamily. Recent evidence, in particular from gene targeting experiments in the mouse, indicates that BMPs are required for mesoderm formation and for the development and patterning of many different organ systems. Significant progress has also been made in understanding the role of BMPs in gastrulation and neurulation in Xenopus and in identifying genes regulating BMP expression and components of the downstream signaling pathways. Extracellular modifiers of BMP activity may constitute an opposing morphogenetic system.

References (57)

  • M Levin et al.

    A molecular pathway determining left—right asymmetry in chick embryogenesis

    Cell

    (1995)
  • DM Kingsley

    The TGF-β superfamily: new members, new receptors, and new genetic tests of function in different organisms

    Genes Dev

    (1994)
  • CM Jones et al.

    Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation

    Development

    (1995)
  • M Moos et al.

    Anti-dorsalizing morphogenetic protein is a novel TGF-β homolog expressed in the Spermann organizer

    Development

    (1995)
  • M Rissi et al.

    Zebrafish radar: a new member of TGF-β superfamily defines dorsal regions of the neural plate and the embryonic retina

    Mech Dev

    (1995)
  • G-Q Zhao et al.

    Evidence that Bmp8a(Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development

    Mech Dev

    (1996)
  • DM Kingsley et al.

    The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGFβ superfamily

    Cell

    (1992)
  • EE Storm et al.

    Limb alterations in brachypodism mice due to mutations in a new member of the TGF-β superfamily

    Nature

    (1994)
  • X Zhou et al.

    Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation

    Nature

    (1993)
  • G Winnier et al.

    Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse

    Genes Dev

    (1995)
  • AT Dudley et al.

    A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye

    Genes Dev

    (1995)
  • G Luo et al.

    BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning

    Genes Dev

    (1995)
  • Y Mishina et al.

    Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis

    Genes Dev

    (1995)
  • WM Gelbert

    The decapentaplegic gene: a TGF-β homologue controlling pattern formation in Drosophila

    Development

    (1989)
  • LA Raftery et al.

    Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila

    Genetics

    (1995)
  • M Fukagawa et al.

    Embryonic expression of mouse bone morphogenetic protein-1 (BMP-1) which is related to the Drosophila dorsoventral gene tolloid and encodes a putative astacin metalloendopeptidase

    Dev Biol

    (1994)
  • E Kessler et al.

    Bone morphogenetic protein-1: the type 1 procollagen C-proteinase

    Science

    (1996)
  • Y Sasai et al.

    Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes

    Cell

    (1994)
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