The Journal of Steroid Biochemistry and Molecular Biology
Multiple splicing variants of the estrogen receptor are present in individual human breast tumors
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Sex-specific effects of 17β-estradiol and dihydrotestosterone (DHT) on growth plate chondrocytes are dependent on both ERα and ERβ and require palmitoylation to translocate the receptors to the plasma membrane
2021, Biochimica et Biophysica Acta - Molecular and Cell Biology of LipidsCitation Excerpt :In many cells, the receptors coexist either as homodimers or as heterodimers [6], but the subcellular distribution of the two receptors does not quite overlap. A number of variant transcripts have been described for both ERα and ERβ [7]. Several of the variant transcripts of the primary ERα and ERβ pre-mRNA retain the same reading frame as the full-length transcript.
Steroidal pheromones and their potential target sites in the vomeronasal organ
2019, SteroidsCitation Excerpt :It is possible that the receptor is outside the membrane and the binding to the steroid causes an effect via a second messenger and opening of ion channels. For some steroid receptors like estrogen receptors different splicing variants have been described [91,92]. It is likely that splicing variants have different affinities to the same ligand.
MicroRNA-135b regulates ERα, AR and HIF1AN and affects breast and prostate cancer cell growth
2015, Molecular OncologyCitation Excerpt :However, AR also regulates a distinct set of genes in the recurrent form of PCa compared to the hormone dependent form of PCa, often in a tissue specific manner (Sharma et al., 2013; Wang et al., 2009). Both ERα and AR splice variants have been identified (Zhang et al., 1996; reviewed in Dehm and Tindall, 2011). ERα and AR splice variants have been suggested to contribute to resistance to endocrine therapy in BCa and to recurrent therapy resistant PCa (Murphy et al., 1998; Kong et al., 2015).
Modulation of Estrogen Receptor Alpha Activity and Expression During Breast Cancer Progression
2013, Vitamins and HormonesCitation Excerpt :Several ERα mRNA splice variants have been identified in various normal tissues and in tumors, including breast cancer (Herynk & Fuqua, 2004). However, the expression of wild-type ERα was shown to be greater than that of the other spliced variants in 109 breast tumors analyzed (Zhang, Hilsenbeck, Fuqua, & Borg, 1996). Several studies have reported a role for certain splice variants in endocrine therapy resistance.
Observations on the presence of E domain variants of estrogen receptor-α in the breast tumors
2006, Journal of Surgical OncologyStructure-function relationship of estrogen receptor α and β: Impact on human health
2006, Molecular Aspects of Medicine