Current Biology
Volume 6, Issue 11, November 1996, Pages 1385-1388
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Protein–protein interactions: PDZ domain networks

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Abstract

PDZ domains can dimerize or bind to the carboxyl termini of unrelated proteins. Crystallographic studies demonstrate the structural basis for these interactions, which contribute to the ability of PDZ domains to create networks associated with the plasma membrane.

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AS Fanning and JM Anderson, Departments of Internal Medicine and Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520-8019, USA.