Current Biology
Volume 9, Issue 6, 25 March 1999, Pages R198-R200
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RNA splicing: What has phosphorylation got to do with it?

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Abstract

Many pre-mRNA splicing factors are phosphorylated in vivo, but the role of this modification has been unclear. Recent observations suggest that phosphorylation modulates protein–protein interactions within the spliceosome, thereby contributing to dynamic structural reorganization of the spliceosome during splicing.

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T Misteli, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. e-mail: [email protected].