Trends in Biochemical Sciences
Protein sequence motifA novel family of predicted phosphoesterases includes Drosophila prune protein and bacterial recJ exonuclease
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Structure of the exopolyphosphatase (PPX) from Zymomonas mobilis reveals a two-magnesium-ions PPX
2024, International Journal of Biological MacromoleculesBiochemical and functional characterization of a thermostable RecJ exonuclease from Thermococcus gammatolerans
2022, International Journal of Biological MacromoleculesA Membrane-Associated DHH-DHHA1 Nuclease Degrades Type III CRISPR Second Messenger
2020, Cell ReportsCitation Excerpt :To further confirm whether SiRe_0244 has cOA degradation activity, we constructed and characterized SiRe_0244 mutants carrying alanine substitutions of conserved residues. SiRe_0244 belongs to the DHH-DHHA1 family, which has five conserved motifs that are important for the activity (Aravind and Koonin, 1998). Sequence alignment of SiRe_0244 and well-characterized bacterial DHH-DHHA1 family proteins show that only three of the five motifs are intact in SiRe_0244 (i.e., D10xD12, D87HH89, and G268GGH271) (Figure S4A).
Role of DHH superfamily proteins in nucleic acids metabolism and stress tolerance in prokaryotes and eukaryotes
2019, International Journal of Biological MacromoleculesCitation Excerpt :Therefore, there is a need of more investigations to understand physiological significance of DHH superfamily members across various forms of life. DHH superfamily has been divided into three subfamilies; subfamily-I, subfamily-II and subfamily-III demarcated on the basis of different domain architectures [5–8]. There are four conserved motifs at amino-terminus of superfamily members.
CRISPR–Cas: Complex Functional Networks and Multiple Roles beyond Adaptive Immunity
2019, Journal of Molecular BiologyCitation Excerpt :The most abundant of the membrane-associated proteins identified in type III systems is CorA, a member of a family of divalent cation channels that is widespread in bacteria and archaea and is the primary route for electrophoretic Mg2+ uptake [135] (Fig. 3a). The CorA protein is encoded in numerous subtype III-B loci with diverse genomic architectures, in many of which the corA gene is adjacent or fused to a gene encoding a DHH family nuclease [136]. Some of these loci also include a gene encoding a predicted nuclease (RNase) of the NYN family [137].