A close family resemblance: the importance of structure in understanding cytochromes P450

doi:10.1016/S0969-2126(98)00109-9

Structure

Volume 6, Issue 9, 15 September 1998, Pages 1079-1085

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Abstract

Cytochromes P450 comprise a very large superfamily of hemeproteins which generally monooxygenate hydrophobic compounds. P450s appear to have a common conserved structural core, yet are variable in regions involved in substrate recognition and binding, and in redox-partner binding. These differences can be identified by an analysis in which structural alignments and homology models are used to compare the various classes and families of P450s.

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JA Peterson and SE Graham, Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, 5323 Harry Hines Blvd, Dallas, TX 75235–9038, USA.

E-mail address for SE Graham (corresponding author): [email protected].

Structure

MinireviewA close family resemblance: the importance of structure in understanding cytochromes P450

Abstract

Minireview
A close family resemblance: the importance of structure in understanding cytochromes P450