Journal of Photochemistry and Photobiology B: Biology
The epidemiology of UV induced skin cancer
Introduction
By skin cancer we mean the three commonest types, basal cell (BCC) and squamous cell (SCC) carcinomas of the skin (also referred to, collectively, as nonmelanocytic skin cancer) and cutaneous malignant melanoma (melanoma).
That UV radiation per se causes these cancers is mainly an indirect inference from evidence that exposure to solar radiation, the main source of exposure to UV radiation, is their main cause and the fact that only UV radiation can damage DNA directly. That solar radiation causes these skin cancers is based on a substantial body of indirect and direct epidemiological studies. These studies are strongly supported by experimental evidence of the capacity of UV radiation to cause SCC and melanoma in animal models. There are no such models for BCC, although the presence of UV “signature mutations” in the TP53 gene in a high proportion of BCCs [1] provides biological evidence to support the epidemiological observations.
This paper summarises, the epidemiological evidence, as it now stands, that sun exposure causes skin cancer and then briefly describes the basis on which a causal role for UV radiation can be inferred from a combination of experimental and epidemiological data. Finally, it describes the key implications of these data for prevention of skin cancer by control of sun exposure.
Section snippets
Incidence by latitude or estimated ambient solar UV
The relationships between incidence rates of BCC and SCC in 1977–1978 and ambient solar UV across a latitude gradient are illustrated in Fig. 1 based on the data of Scotto et al. [2]. Rates increased with increasing estimated ambient solar UV (from Robertson-Berger meter observations of erythemal UV expressed as annual number of meter counts by 10−4) in ten US metropolitan populations from 47.5° N (Seattle) to 30.0° N (New Orleans). The values of R2 for the exponential relationships plotted in
Evidence that UV radiation per se causes skin cancer in humans
There is no practical way that the action spectrum for skin cancer can be measured directly in humans. Inferences, however, can be made about it in a number of ways.
First, the action spectrum for SCC has been rigorously determined experimentally in albino hairless mice [28]. This action spectrum shows an initial peak at 293 nm in the UVB range, falls to a trough at 354 nm of between 10−4 and 10−5 of the effect at the peak, rises to another small peak at 380 nm in the UVA range (still nearly 10−4
Comment
In 1992, an expert working group of the International Agency for Research on Cancer reviewed all the evidence for carcinogenicity of solar and ultraviolet radiation [33]. It concluded that: “There is sufficient evidence in humans for the carcinogenicity of solar radiation. Solar radiation causes cutaneous malignant melanoma and nonmelanocytic skin cancer”. All the epidemiological evidence that has accumulated since 1992 has strengthened this qualitative conclusion.
While we, like the
Acknowledgements
We thank Chris Goumas for doing the summary analysis of results of studies of sun exposure and nonmelanocytic skin cancer.
References (41)
- et al.
Ultraviolet radiation induced signature mutations in photocarcinogenesis
J. Investig. Dermatol. Symp. Proc.
(1999) - et al.
Malignant transformation of solar keratoses to squamous cell carcinoma
Lancet
(1988) - et al.
Relative importance of prior basal cell carcinomas. Continuing sun exposure, and circulating lymphocytes-T on the development of basal cell carcinoma
J. Investig. Dermatol.
(1992) - et al.
Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial
Lancet
(1999) - et al.
Incidence of Nonmelanoma Skin Cancer in the United States
(1983) - et al.(1987)
- et al.
Relationship of melanoma and other skin cancer mortality to latitude and ultraviolet radiation in the United States and Canada
Int. J. Epidemiol.
(1974) - et al.
Epidemiological support for an hypothesis for melanoma induction indicating a role for UVA radiation
Photochem. Photobiol.
(1999) Melanoma of the skin
Br. Med. Bull.
(1984)Melanoma: childhood or lifelong sun exposure
A dose–response curve for sun exposure and basal cell carcinoma
Int. J. Cancer
Case-control study of sun exposure and squamous cell carcinoma of the skin
Int. J. Cancer
The use of spectrophotometry to estimate melanin density in Caucasians
Cancer Epidemiol. Biomarkers Prevent.
Pigmentary and cutaneous risk factors for non-melanocytic skin cancer: a case-control study
Int. J. Cancer
Demographic characteristics, pigmentary and cutaneous risk factors for squamous cell carcinoma of the skin: a case-control study
Int. J. Cancer
Pigmentary traits, ethnic origin, benign nevi, and family history as risk factors for cutaneous malignant melanoma
J. Natl. Cancer Inst.
Melanoma and sun exposure: an overview of published studies
Int. J. Cancer
A non-invasive measure of photoageing
Int. J. Epidemiol.
Pigmentation and skin reaction to sun as risk factors for cutaneous melanoma
Br. Med. J. (Clin. Res. Ed.)
Sunlight exposure, pigmentary factors, and risk of nonmelanocytic skin cancer. I. Basal cell carcinoma
Arch. Dermatol.
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