Original reportHypertension, Heart Rate, Use of Antihypertensives, and Incident Prostate Cancer
Section snippets
Selected Abbreviations and Acronyms
CHS = Cardiovascular Health Study HR = hazard ratio CI = confidence interval BMI = body mass index
The Cohort
The Cardiovascular Health Study (CHS) is a cohort of 5201 adults over age 65 recruited from a random selection of HCFA records in 1989/90 from four U.S. communities (Forsyth County, NC; Sacramento County, CA; Washington County, MD; and Pittsburgh, PA) (15). In 1992/93 an additional 687 individuals of black race were added to the cohort. Recruitment criteria into the CHS included being age 65 at time of initial examination, non-institutionalized, and able to give informed consent; those who were
Incident Prostate Cancer
A total of 209 cases of incident prostate cancer were assessed between June 1, 1989 and June 31, 1996. One hundred thirty of these cases were ascertained using ICD-9 codes from the hospital abstraction data. An additional 79 cases were identified from self-report of prostate cancer from the medical history form completed at each clinic visit. A total of 13,009 person years of follow-up accrued, resulting in an incident prostate cancer rate of 16.1 per 1000 person-years at risk.
Hypertension Status
At entry into the
Cancer and Hypertension
In this article, we present data from a cohort that included 2442 men age 65 and older suggesting that, after controlling for other known risk factors (age, race, and obesity), an increased risk of incident prostate cancer may be associated with increased heart rate and that a decreased risk may be found with use of antihypertensives. Evidence was lacking on an association with hypertension at entry into the study and subsequent prostate cancer. The literature contains very few studies focusing
Acknowledgements
Supported in part by contracts N01-HC-85079 through N01-HC-85086 from the National Heart, Lung, and Blood Institute.
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