Near-Infrared Optical Imaging of the Breast with Model-Based Reconstruction☆
Section snippets
Materials and Methods
Our near-infrared optical imager is an automated, multichannel frequency-domain system (we needed only direct current [DC] measurements to reconstruct the optical images reported herein). In the clinical measurements, an intensity-modulated light from a 785-nm 50-mW diode laser (Thorlabs, Newton, NJ) was sent sequentially, via an automatic moving stage (17NST101; Melles-Griot, Cambridge, England), to 16 3-mm fiberoptic bundles attached to the breast. For each source position, the diffused light
Results
We have completed a pilot series of optical breast examinations in nine women (five white, three black, and one Hispanic; age range, 32–62 years). Patients of differing races were studied to see if skin color affected results. The protocol was approved by the institutional review board, and the study was conducted in full compliance with the accepted standards for research involving human subjects. Except for control cases, patients entering the study had a suspicious mammogram or palpable
Discussion
In this pilot clinical evaluation of an optical imaging system, we obtained two types of images, absorption and scattering, from a single plane. Physically, these represent two different intrinsic properties of breast tissue. For all absorption images, breast masses demonstrated increased absorption relative to the background tissue. Increased blood volume associated with a rapidly growing tumor is the primary cause of this increase in absorption. This assumption has been supported by in vitro
References (35)
- et al.
Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy
Neoplasia
(2000) - et al.
Sources of absorption and scattering contrast for near-infrared optical mammography
Acad Radiol
(2001) - et al.
Selective use of image-guided large-core needle biopsy of the breast: accuracy and cost-effectiveness
AJR Am J Roentgenol
(1995) - et al.
US-guided core breast biopsy: use and cost-effectiveness
Radiology
(1998) - et al.
Ability of mammography to reveal nonpalpable breast cancer in women with palpable breast masses
AJR Am J Roentgenol
(1999) - et al.
Recent developments in breast imaging
Phys Med Biol
(1996) - et al.
Optical properties of normal and diseased human breast tissue in the visible and near infrared
Phys Med Biol
(1990) - et al.
Spectroscopy and imaging with diffusing light
Phys Today
(1995) - et al.
Time-resolved spectroscopy of mitochondria, cells, and rat tissues under normal and pathologic conditions
Proc IEEE
(1995) - et al.
Noninvasive measurements of breast tissue optical properties using frequency-domain photon migration
Philos Trans R Soc Lond B Biol Sci
(1997)
Assessment of the size, position, and optical properties of breast tumors in vivo by noninvasive optical methods
Appl Opt
Development of a time-domain optical mammograph and first in vivo applications
Appl Opt
Infrared diaphanoscopy for medical diagnosis
Ultrafast time-gated imaging in thick tissues: a step towards optical mammography
Opt Lett
A novel approach to laser tomography
Bioimaging
Imaging of spontaneous canine mammary tumors using fluorescent contrast agents
Photochem Photobiol
Resolution limits for imaging through turbid media with diffuse light
Opt Lett
Cited by (135)
Dynamic vascular optical tomographic imaging for peripheral artery disease and breast cancer
2018, Neurophotonics and Biomedical SpectroscopyDielectric properties of the normal and malignant breast tissues in xenograft mice at low frequencies (100 Hz–1 MHz)
2017, Measurement: Journal of the International Measurement ConfederationCitation Excerpt :It is noteworthy that the tumor-to-background EP ratios measured in this study are significantly higher than ratios obtained for some other tissue physical properties (e.g. light absorption). For instance in optical imaging, near infrared (NIR) absorption and hemoglobin concentration levels in tumors are only 2–4 higher in comparison with healthy breast tissues [28]. The measured dielectric properties of the ten specimens also indicated that the standard deviation of the permittivity values are reasonably low (8–21%) at all frequencies.
A Way to Improve The Resolution of Breast Diffuse Optical Tomography
2022, Progress in Biochemistry and BiophysicsExtending dynamic range of detector in non-contact diffuse optical tomography system using deep learning
2021, Guangxue Jingmi Gongcheng/Optics and Precision Engineering
- ☆
The Department of Radiology, Medical University of South Carolina, Charleston (L.F.B.).
Supported in part by grants from the National Institutes of Health (CA 78334) and the Greenville Hospital System/Clemson University Biomedical Cooperative.