REVIEW ARTICLE
Humanized Antibodies as Potential Therapeutic Drugs

https://doi.org/10.1016/S1081-1206(10)62794-9Get rights and content
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Background

Antibodies have been used therapeutically to treat a variety of clinical conditions. The introduction of monoclonal antibodies and more recently, engineered humanized antibodies has greatly refined and expanded the therapeutic potential of this modality of treatment.

Learning objectives

To reinforce the reader's knowledge of the therapeutic application of antibody in the treatment for different diseases. More specifically, to enhance the reader's understanding of basic methods employed in the production and clinical use of humanized antibodies.

Data source

The MEDLINE database was used to review the humanized antibody related literature.

Conclusion

Humanized antibodies provide a novel approach for the treatment of a broad range of diseases. Expanded use will depend on improvement in their efficacy (avidity and specificity), demonstration of their safety, and reduction of their immunogenicity.

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Supported by a grant from Zeneca Pharmaceuticals