Elsevier

Microbes and Infection

Volume 4, Issue 2, February 2002, Pages 189-199
Microbes and Infection

Review
Nef: agent of cell subversion

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Abstract

Primate lentiviruses encode a small protein designated Nef that has been shown to be a major determinant of virus pathogenicity. Nef regulates multiple host factors in order to optimize the cellular environment for virus replication. The mechanisms by which this small protein modulates distinct host cell properties provide intriguing insight into the intricate interaction between virus and host.

Keywords

Gene products, nef
Genes, nef
HIV
SIV
Acquired Immunodeficiency Syndrome
p21-activated kinase 2
Antigens, CD4
HLA antigens

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