Original articleDeterminants of health-related quality of life in patients with chronic liver diseases
Section snippets
Patients
Consecutive adult patients with a diagnosis of a chronic liver disease, confirmed by laboratory tests, imaging studies, and, in most cases, liver histological examination, attending a referral center for patients with liver diseases were invited to take part in the study. Enrollment started August 2001 and ended August 2002. Non-German-speaking patients, patients after liver transplantation, those with dementia or psychosis, and patients with refractory encephalopathy (≥ grade II), preventing
Results
Twenty-four patients were excluded because of their inability to understand German or cognitive deficiencies caused by alcoholic cerebral damage or lethal complications of the liver disease. Of the 255 consecutive patients approached, 203 patients (80%) agreed to participate in the study and completed questionnaires. There were no differences in terms of sex, age, and cause of liver disease in patients who agreed and did not agree to take part in the study. Of those who agreed, not all provided
Discussion
This is the first study with simultaneous assessment of the determination of HRQOL in patients with mixed chronic liver diseases by variables of the liver disease, sociodemographic variables, and active medical and psychiatric comorbidity. Our study shows that patients with chronic liver disease perceive significantly impaired HRQOL compared with the German general population. The reduced overall HRQOL in patients with chronic liver diseases can be predicted best by psychiatric and active
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