Contribution of myeloid-derived suppressor cells to tumor-induced immune suppression, angiogenesis, invasion and metastasis
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2021, Clinics in Plastic SurgeryThe impact of microRNAs on myeloid-derived suppressor cells in cancer
2021, Human ImmunologyCitation Excerpt :These were previously described to initiate additional immunosuppressive mechanisms of MDSCs [29]. Also, there is increasing evidence that MDSCs are activated, and stimulated by tumor-derived agents that mainly function in tumor expansion, angiogenesis, and metastasis [26,30]. These cells are established to secrete basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) to endorse tumor neovascularization [31].
Expansion of PMN-myeloid derived suppressor cells and their clinical relevance in patients with oral squamous cell carcinoma
2019, Oral OncologyCitation Excerpt :Therefore, the identification of the mechanisms underlying the immune dysfunction associated with aggressive tumor growth and treatment responses is important for the effective management of OSCC. Myeloid-derived suppressor cells (MDSCs) are immune-suppressive cells with the ability to suppress T cell activation and function [7-9]. MDSCs were initially investigated in malignant diseases based on their important role in the regulation of immune responses in patients with tumors.