EditorialSpecial issue on transport ATPases
References (3)
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J. Biol. Chem.
(1972)
Cited by (3)
Altered signaling pathways linked to angiotensin II underpin the upregulation of renal Na<sup>+</sup>-ATPase in chronically undernourished rats
2014, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :Conversely, a decreased PKA-mediated phosphorylation at Ser462 situated between the E and G motifs could be a candidate for modulation that also culminates in enhanced nucleotide binding and catalytic phosphorylation. Besides these regulatory phosphorylations with high scores in renal Na+-ATPase – that could be deregulated in BRD rats as a consequence of locally stimulated Ang II-pathways – other phosphorylatable residues (Thr54 and Thr81) could be involved through long-range intramolecular communications, as proposed for several P-ATPases [61,62]. These communications are the ones that probably were altered under prolonged chronic undernutrition as a possible consequence of deregulated local Ang II signaling.
Inorganic phosphate uptake in Trypanosoma cruzi is coupled to K<sup>+</sup> cycling and to active Na<sup>+</sup> extrusion
2013, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :These inhibitory effects could be explained by the hypothesis – proposed some years ago for the Na+:Pi exchange in P. falciparum [16] – that the rate-limiting step in catalysis, and therefore of net Pi influx, is the membrane potential-dependent re-orientation of the negatively charged symporters within the membrane phase. Charged domains in both membrane transporters can be re-oriented owing to long-range intramolecular conformational changes that follow binding/dissociation of ligands [45]. As pointed out above, the (H+ + K+)ATPase and the asymmetrical distribution of H+ and K+ appear to play a central role in generating the membrane potential and this probably explains the inhibitory effects of SCH28080, FCCP and valinomycin on both components of Pi uptake.
Calcium and copper transport ATPases: Analogies and diversities in transduction and signaling mechanisms
2011, Journal of Cell Communication and Signaling
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