Elsevier

Addictive Behaviors

Volume 32, Issue 1, January 2007, Pages 194-198
Addictive Behaviors

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Does expectancy affect alcohol absorption?

https://doi.org/10.1016/j.addbeh.2006.03.042Get rights and content

Abstract

Many factors influence alcohol absorption, yet few studies have addressed the issue of whether or not experimental manipulations themselves may affect alcohol absorption. The current balanced placebo design study comparing the expectancy effects of root beer and non-alcoholic beer vehicles resulted in significantly lower blood alcohol levels in the root beer condition than in the beer condition even though alcohol doses were the same. Two possible explanations are discussed; differences in expectancy may have affected absorption, or fructose in the root beer may have slowed absorption of alcohol relative to the maltose in beer. The literature does not provide strong evidence for either of the hypotheses. The implication of this study's results is that alcohol absorption rate may be an important source of confounding effects in behavioral research in the laboratory, because it may be affected by beverages or other experimental conditions.

Section snippets

Participants

Twenty-five healthy beer drinkers without alcohol problems participated. Their ages ranged from 21 to 47 years, averaging 29.73 years for the 11 men and 29.43 years for the 14 women. Participants' normal alcohol intake quantity ranged from one to seven drinks per occasion and frequency from 5 to 182 occasions per year.

Procedures

Participants were asked not to use alcohol or other drugs (with the exception of caffeine and nicotine) for 12 h, fast for at least 1.5 h and abstain from caffeine for 2 h prior

Results

Correlations among participants' = weights, drinking variables, smoking quantity at the 15-min and 30-min BAC readings for both flavor conditions were not significant. There were no gender differences in the BAC estimates for any of the six measurement times (see Fig. 1).

A repeated measures (2 within-subjects factors × time) analysis of variance was used to analyze the effects of the flavor × alcohol dose manipulations. The first breath analyzer readings taken about 5 min after the participants

Discussion

There are two possible explanations why the BACs were higher in the beer condition than in the root beer condition, different congeners or differences in expectancy. There is no research with human subjects that compares the congeners (fructose in root beer and maltose in beer) used in this experiment. However, research with rats found that the fructose delayed the alcohol absorption while maltose hastened the absorption (Broitman, Gottlieb, & Vitale, 1976). Another possible explanation for our

Acknowledgements

This research was supported in part by the BRIN Program of the National Center for Research Resources, NIH Grant P20 RR16471-03 to Shirley Cole-Harding. The authors wish to thank the many student research assistants, especially Charles Inman, Clare Pettis and Alana Tergeson, without whom the research could not have been done, and our colleagues, Drs. Don Burke, Deb Olson and Paul Markel for their help in reviewing the manuscript.

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