Original articleAvellino Corneal Dystrophy Worsening after Laser In Situ Keratomileusis: Further Clinicopathologic Observations and Proposed Pathogenesis
Section snippets
Methods
The condition, along with other types of granular corneal dystrophies, lattice corneal dystrophies, and Reis-Buckler dystrophy, results from a specific mutation in the BIGH3 gene on chromosome 5q31, dictating a TGF-beta (TGFB)-induced cell adhesion protein, keratoepithelin (68 Kda), which is mainly expressed by the corneal epithelium and normally present in the corneal stroma, with highest density in the Bowman layer.9, 10, 18, 19, 20 In the case of Avellino corneal dystrophy, a mutation in
Discussion
Recurrence of ACD as well as granular and lattice dystrophies has been documented after treatment by PTK and PRK.11, 12 Worsening ACD has also been reported after LASIK.13, 14, 15, 16, 17, 18, 19 The deposits were described clinically and histologically to be located in the LASIK flap interface and the stroma anterior to it. Three reports have so far described histopathologic findings in eyes with ACD after LASIK. One of those reports, published by Aldave and associates, describes the findings
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