Original articleBevacizumab in Inflammatory Eye Disease
Section snippets
Methods
We performed a retrospective chart review of eyes treated with intravitreal bevacizumab for uveitic CNV or CME through February 1, 2008. A computerized search of billing codes was used to identify eligible patients at the Bascom Palmer Eye Institute. Inclusion criteria consisted of a diagnosis of inflammatory CNV or CME, treatment with at least one injection of intravitreal bevacizumab, and follow-up of at least 1 month. Eyes were excluded if they had received sub-Tenon or intravitreal
Results
TABLE 1, TABLE 2 summarize demographic and ophthalmic results. Thirty-four eyes of 30 patients met inclusion criteria; an additional 4 eyes were excluded because they had received sub-Tenon or intravitreal corticosteroids during the 12 weeks preceding bevacizumab injection. Twenty-one eyes of 19 patients (9 male, 10 female) with a median age of 52 years (range, 7 to 83) demonstrated CNV while 13 eyes of 11 patients (4 male, 7 female) with a median age of 67 years (range, 17 to 83) demonstrated
Discussion
Although case reports have described favorable outcomes in cases of inflammatory CNV and CME treated with intravitreal bevacizumab,25, 26, 27, 28 larger series contain less consistent results. Adan and associates, for example, retrospectively reviewed the outcomes of 9 eyes treated with intravitreal bevacizumab for uveitic CNV.29 Over a mean follow-up of 7.1 months, they found that BCVA improved in 8 eyes (88.8%) and stabilized in 1 (11.2%); foveal thickness decreased in all eyes, a result that
References (33)
- et al.
Punctate inner choroidopathy
Am J Ophthalmol
(1984) - et al.
Subfoveal and juxtafoveal subretinal neovascularization in the presumed ocular histoplasmosis syndromeVisual prognosis
Ophthalmology
(1984) - et al.
Visual prognosis of multifocal choroiditis, punctate inner choroidopathy, and the diffuse subretinal fibrosis syndrome
Ophthalmology
(1996) - et al.
Birdshot chorioretinopathy: long-term manifestations and visual prognosis
Ophthalmology
(2004) - et al.
Ocular complications of pediatric uveitis
Ophthalmology
(2004) - et al.
Patterns of macular edema in patients with uveitis: qualitative and quantitative assessment using optical coherence tomography
Ophthalmology
(2004) - et al.
Serpiginous choroiditis
Surv Ophthalmol
(2005) - et al.
Aqueous humor and plasma vascular endothelial growth factor in uveitis-associated cystoid macular edema
Am J Ophthalmol
(2001) - et al.
Photodynamic therapy of idiopathic and inflammatory choroidal neovascularization in young adults
Ophthalmology
(2003) - et al.
Intravitreal bevacizumab for the management of choroidal neovascularization in age-related macular degeneration
Am J Ophthalmol
(2006)
Aqueous humor and plasma vascular endothelial growth factor in uveitis-associated cystoid macular edema
Am J Ophthalmol
Sympathetic ophthalmia and choroidal neovascularizationCase report
Arch Ophthalmol
Causes and frequency of blindness in patients with intraocular inflammatory disease
Br J Ophthalmol
Vascular endothelial growth factor and the eye: biochemical mechanisms of action and implications for novel therapies
Ophthalmic Res
Inhibitors of ocular neovascularization: promises and potential problems
JAMA
Corticosteroids as an antiangiogenic agent for histoplasmosis-related subfoveal choroidal neovascularization
J Ocul Pharmacol Ther
Cited by (0)
Supplemental Material available at AJO.com.