General Obstetrics and Gynecology: ObstetricsMidpregnancy genitourinary tract infection with Chlamydia trachomatis: Association with subsequent preterm delivery in women with bacterial vaginosis and Trichomonas vaginalis
Section snippets
Material and methods
The current study represents an ancillary investigation that was conducted as a part of 2 separate but concurrently performed randomized clinical trials. The 2 parent trials were conducted by the NICHD Maternal-Fetal Medicine Units Network, and the primary reports of these 2 parent trials have been previously published.15, 16 In both trials, women were screened between 8 weeks 0 days and 22 weeks 6 days of gestation for bacterial vaginosis and Trichomonas vaginalis infection. Eligibility and
Results
A total of 2570 women were enrolled in the 2 parent trials. Of these, 2470 had a ligase chain reaction result available at the randomization or follow-up visit and were included in our analysis for this ancillary study. The prevalence of C. trachomatis infection based on the ligase chain reaction assay of voided urine specimens collected at the randomization visit was 9.9% (238 of 2398) and 10.0% (208 of 2089) among specimens collected at the follow-up visit. A total of 14.1% of the 2017 women
Comment
The role of genital tract infection as a potentially preventable or reversible etiology of preterm delivery has been the subject of intense research in recent years.3, 20, 21, 22 Indeed, the potential effectiveness to prevent preterm delivery of an antibiotic treatment for lower genital tract infections such as bacterial vaginosis23, 24, 25 and T. vaginalis26 was the basis of the 2 parent trials for this ancillary study conducted by the NICHD Maternal-Fetal Medicine Units Network.15, 16 The
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Cited by (59)
Chlamydia trachomatis screening in preterm labor: A systematic review and meta-analysis
2019, European Journal of Obstetrics and Gynecology and Reproductive BiologyReview: Maternal health and the placental microbiome
2017, PlacentaCitation Excerpt :All bacteria are not created equal, and there exists significant discordance between cultivation-dependent bacterial identification and clinical pregnancy outcomes [74]. It will be interesting to determine whether this gap is bridged as cultivation-independent techniques become more widely utilized in routine diagnostics [37–40]. Finally, clinical management of infection-related pregnancy morbidity may benefit from knowledge gained as a result of cultivation-independent studies.
Management of preterm labor
2016, Journal de Gynecologie Obstetrique et Biologie de la ReproductionAssociations between maternal syphilis infection during pregnancy and low birth weight and preterm birth: a prospective cohort study
2023, Archives of Gynecology and Obstetrics
Supported by the National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network (U10 HD21410, U10 HD21414, U10 HD27869, U10 HD27917, U10 HD27905, U10 HD27860, U10 HD27861, U10 HD27883, U10 HD27889, U10 HD27915, U10 HD34122, U10 HD34116, U10 HD34210, U10 HD34208, U10 HD34136, U01 HD19897, and U01 HD36801) and was also partially supported by a contract from the Agency for Health Care Policy and Research (contract 290-92-0055) and a grant from the National Institute of Allergy and Infectious Diseases (AI 38514).
Reprints not available from the authors.