ReviewObstetricsAntenatal magnesium sulfate for the prevention of cerebral palsy in preterm infants less than 34 weeks' gestation: a systematic review and metaanalysis
Section snippets
Materials and methods
The systematic review was conducted after a prospectively prepared protocol and reported using the Quality of Reporting of Metaanalysis (QUOROM) guidelines for metaanalysis of randomized controlled trials.23
Results
The flow of the search is shown in Figure 1. Of the 331 potentially relevant citations identified, 5 studies (6 trials) published in 7 articles fulfilled the inclusion criteria after a detailed review of 92 studies.29, 30, 31, 32, 33, 34, 35 Because the study by Mittendorf et al29, 30 had 2 arms (tocolytic and neuroprotective), it was considered as 2 separate trials in this review. Of the other 4 studies included, 3 studies31, 33, 35 evaluated magnesium sulfate as an infant neuroprotective
Comment
In this systematic review, we found persuasive evidence that magnesium sulfate administered to women at high risk of delivery before 34 weeks of gestation reduces the risk of cerebral palsy in their children. The evidence was strongest for the subgroup of trials that specifically evaluated the use of antenatal magnesium sulfate in preventing cerebral palsy. In addition, this therapy was also associated with a significantly decreased risk of moderate or severe cerebral palsy and substantial
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Supported was provided by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services.
Reprints not available from the authors.