Coronary artery diseaseImpact of body mass index on the outcome of patients with multivessel disease randomized to either coronary artery bypass grafting or stenting in the ARTS trial: The obesity paradox II?
Section snippets
Study design
A total of 1,205 patients who had multivessel coronary artery disease and considered equally treatable with the 2 modalities were randomized to stenting (n = 600) or CABG (n = 605) between April 1997 and June 1998 at 67 participating centers worldwide as part of the ARTS trial. Details of this study have been described previously.12, 13 In brief, patients who had not had a previous revascularization procedure were included in the study. Inclusion criteria included stable or unstable angina,
Clinical and angiographic characteristics of patients
Data on 1,203 consecutive patients who underwent PCI were available for complete analysis (2 patients did not have complete data for calculation of BMI). Fifty percent of patients were overweight and 72% were overweight or obese, with only 28% having a normal BMI in the 2 study arms. Baseline clinical characteristics of all patients are presented in Table 1, and angiographic and periprocedural characteristics are listed in Table 2.
Clinical outcomes
Three-year clinical outcomes for all BMI groups are presented in
Discussion
In this study, we analyzed the effect of BMI on 3-year outcomes of a large cohort of patients who had multivessel coronary disease and were randomized to percutaneous revascularization with stents or CABG as part of the ARTS trial. We observed that patients who had a normal BMI (<24.9 kg/m2) had similar survival rates without major adverse cardiac or cerebrovascular events (including death, cerebrovascular events, myocardial infarction, or repeat revascularization) regardless of type of
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