Heart failureEpidemiology, Associated Factors, and Prognostic Outcomes of Renal Artery Stenosis in Chronic Heart Failure Assessed by Magnetic Resonance Angiography
Section snippets
Methods
All participants provided written informed consent, and the study was carried out in accordance with the Declaration of Helsinki and the European Standards for Good Clinical Research Practice. Ethical approval was granted by the Local Research Ethics Committee.
This was a single center, observational, prospective study. Cross-sectional data were used to determine prevalence and longitudinal data were analyzed to assess changes and prognostic outcomes.
All patients were enrolled from a
Results
The average age of the population was 70 ± 1 years; 77% were men and had a mean left ventricular ejection fraction of 36 ± 1 %. Table 1 shows the prevalence of RAS in the whole population separated by the left or right renal artery. Eighty-nine patients (66%) had some degree of RAS, 73 (54%) had RAS of >50%, and 32 (24%) had bilateral RAS of >50%. The baseline demographic, clinical, and laboratory characteristics of the patients, divided by the presence or absence of RD are given Table 2.
Discussion
This is the first study to demonstrate that RAS is associated with an increase in morbidity and mortality in patients with chronic HF. We have also confirmed that RAS is common and associated with RD in this population.
There are only a few reports on the prevalence of RAS in patients with chronic HF. One involved 86 patients with heart failure aged >70 years (mean, 77.5, 49% women) who had a serum creatinine <300 μmol/l (34 mg/ml) and were ACE inhibitor naïve. The potential of renal MRA to
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2023, American Journal of the Medical SciencesCitation Excerpt :Heart failure exacerbations alone are responsible for almost one million hospitalizations in the United States each year.1 Multiple studies have shown patients with HF may have concomitant RAS, however most of these studies included subjects from outpatient heart failure clinics.2,3 The management of RAS among hypertensive patients was assessed in the CORAL trial,4,5 however management of RAS in subjects hospitalized with acute HF remains controversial.6
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