MiscellaneousDifferences in Atherosclerotic Profiles Between Patients With Thoracic and Abdominal Aortic Aneurysms
Section snippets
Methods
We retrospectively studied the clinical data of 343 consecutive patients, comprising 132 patients with TAA and 211 patients with AAA, who were admitted to our hospital for elective repair of aortic aneurysms between July 2001 and December 2004. Exclusion criteria were Marfan syndrome (n = 10), Ehlers–Danlos syndrome (n = 0), annuloaortic ectasia (n = 11), bicuspid aortic valve (n = 2), infectious aortitis (n = 2), aortitis syndrome (n = 15), thoracoabdominal aortic aneurysm (n = 33), and
Results
The study population consisted of 132 patients with TAA and 211 with AAA. The baseline demographic and clinical characteristics of the patients are listed in Table 1. There were a significantly greater number of men and smokers in the AAA group compared with the TAA group. Body mass index was significantly less in patients with AAA than in those with TAA. Age, creatinine clearance, and C-reactive protein level were similar in the 2 groups. Comorbidities of the patients are also listed in Table 1
Discussion
In the present study, we sought to determine to what extent atherosclerosis contributes to the development of TAA and to elucidate the differences in atherosclerotic profiles between patients with TAA and those with AAA. The results of the study demonstrated that features of atherosclerosis disease and morphologies of the aneurysms differ considerably between patients with TAA and those with AAA. Specifically, patients with TAA were at risk for high body mass index, hypertension, and cerebral
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This work was supported by grants H16-009, H16-017, and H17-009 from the Health and Labor Sciences Research; research grants for Cardiovascular Disease 16C-6; and 18C-4 from the Ministry of Health, Labor and Welfare; and grants from the Japan Cardiovascular Research Foundation.