Arrhythmias and conduction disturbanceUsefulness of Single Nucleotide Polymorphism in Chromosome 4q25 to Predict In-Hospital and Long-Term Development of Atrial Fibrillation and Survival in Patients Undergoing Coronary Artery Bypass Grafting
Section snippets
Methods
TexGen is a collaborative, prospective genetic registry that enrolls patients with any personal or family history of cardiovascular disease who seek care at several institutions within the Texas Medical Center system, including the University of Texas Health Science Center, the University of Texas M. D. Anderson Cancer Center, and Baylor College of Medicine and their affiliated hospitals, and the Texas Heart Institute at St. Luke's Episcopal Hospital. The cohort included patients admitted with
Results
Of the patients undergoing CABG enrolled in the TexGen database (n = 1,568), 1,166 patients identified their race as white. This group represented the final population included in the present analyses. The baseline characteristics of these patients are listed in Table 1. The mean age of the cohort was 65 years, and the proportion of men was greater. The prevalence of hypertension and patients with New York Heart Association functional class III-IV symptoms was high, and 10% of the patients
Discussion
In the present prospective analysis from the TexGen cohort, we found that variants in chromosome 4q25 were associated with postoperative AF, the long-term development of AF, and long-term mortality. We also found that the associations between these polymorphisms and postoperative AF could possibly be increased by the use of preoperative BBs.
Our results support the findings from an earlier study that polymorphisms in chromosome 4q25 are associated with the development of postoperative AF.9 The
Acknowledgment
We are extremely grateful to the patients, their families, and the physicians involved in the TexGen study. We also wish to acknowledge Joanna A. Brooks, BA, for her editorial assistance with our report.
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Cited by (35)
Role of single nucleotide polymorphisms in susceptibility of stroke: A systemic review
2021, Meta GeneCitation Excerpt :A meta-analysis carried out by Kääb et al. (2009) suggested that these two SNPs are associated with AF in individuals of European descent. Furthermore, a study of Caucasian individuals also revealed an association of these two SNPs with long-term AF with OR = 1.32 for rs2200733 SNP and OR = 1.28 for rs10033464 SNP (Virani et al. 2011). Interestingly, these two SNPs were also found to be directly associated with cardioembolic stroke in an Icelandic population with OR = 1.52 for rs2200733 SNP and OR = 1.27 for rs10033464 SNP (Gretarsdottir et al. 2008).
Perioperative Genomics
2018, Genomic and Precision Medicine: Cardiovascular Disease: Third EditionAtrial Fibrillation Genetics: Is There a Practical Clinical Value Now or in the Future?
2016, Canadian Journal of CardiologyGenetic variation in the β<inf>1</inf>-adrenergic receptor is associated with the risk of atrial fibrillation after cardiac surgery
2014, American Heart JournalCitation Excerpt :Indeed, our analyses validated the association of many of the previously described covariates with PoAF. However, we did not include other genetic markers known to predict PoAF, for example, markers in the 4q25 locus.21,32 Yet, these markers are not located on the same chromosome as the ADRB1 gene, and it is therefore likely that the effect of rs1801253 is independent of theirs.
Single nucleotide polymorphisms in cholesteryl ester transfer protein gene and recurrent coronary heart disease or mortality in patients with established atherosclerosis
2013, American Journal of CardiologyCitation Excerpt :TexGen is a prospective, collaborative genetic registry enrolling patients with atherosclerotic CHD who seek care at multiple institutions within the Texas Medical Center.18,19
This work was supported by grant 08RDM003 from the Roderick D. MacDonald research fund, St. Luke's Episcopal Hospital (Houston, Texas). Dr. Virani was supported by Career Development Award CDA-09-028 from the Department of Veterans Affairs Health Services Research and Development Service (Washington, DC). This work was also supported by grants National Institutes of Health UL1 RR024148 and 1R01NR010235-01A1 through the TexGen Foundation (Houston, Texas) and funded by the National Institute of Nursing Research (Washington, DC).
The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs.